Cisdiamminedichloroplatinum

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August undefined, 2024

Web目的应用免疫组化方法观察豚鼠内耳S-100蛋白的表达。方法选用健康,Preyer’s反射正常豚鼠8只,4%多聚甲醛活体灌注后耳蜗冰冻切片,采取SP免疫组化方法进行S-100蛋白染色。结果耳蜗Corti’s器内外毛细胞,Deiter及Hensen细胞呈阳性表达,基底膜下细胞未着色,螺旋缘齿间细胞,螺旋神经节细胞间纤维,螺旋韧带及 ... WebAbstract. Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. …

Enhanced DNA repair as a mechanism of resistance to cis ...

WebMar 1, 1979 · 1. Cisplatin is a co-ordination complex of a central platinum atom, two chlordies and two ammonia molecules in the “ cis ” position. 2. A prime mechanism of … WebWe demonstrated previously that the effect of cis-diamminedichloroplatinum(II) (cisplatin) against pancreatic cancer was substantially enhanced by the addition to the … cryptic 26245

trans-Platinum(II) diamminedichloride Cl2H6N2Pt+2

WebSep 1, 1990 · The specific drug combination and experimental growth system for this introductory application was that of 1-β- d -arabinofuranosylcytosine (ara-C) and cisplatin with simultaneous drug exposure (1, 3, 6, 12, or 48 h) against L1210 leukemia in vitro. WebFeb 25, 2016 · Platinum, being a 5d metal, has d orbitals that are larger than the 3d orbitals, allowing for a more spread out electron density. That decreases the coulombic repulsion energy, which we will call Πc. The … WebApr 20, 2016 · miR-3188 suppresses cell growth and 5-FU chemoresistance. To identify the role of miR-3188 in NPC development, we first examined its expression levels in normal epithelium (NP) and NPC cell lines. miR-3188 expression was elevated in NP69 and SXSW-1489 cells but weakly expressed in NPC cells (Fig. 1a).To further explore its biological … duphd.ac.in

Adducts of the antitumor drug cis-diamminedichloroplatinum(II

cis-Diamminedichloroplatinum AMERICAN ELEMENTS

WebDec 3, 1979 · [Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)] Platinum coordination complexes represent a new class of antineoplastic agents among which only cis-diamminedichloroplatinum(II) (cis-DDP) has undergone extensive clinical trials. WebCisplatin (cisdiamminedichloroplatinum) for treatment of transitional cell carcinoma of the urinary bladder or urethra. J Vet Intern Med. May-Jun 1990;4(3):148-52.doi: 10.1111/j.1939-1676.1990.tb00888.x. Authors A S Moore 1 , A Cardona, W … cryptic 26341WebCisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cancer Treat Rev. 1979 Mar;6(1):17-39. doi: … cryptic 26311

"WebAbstract Cis-diamminedichloroplatinum (DDP) was used as the initial treatment in a pilot study of 17 patients with biopsy-proven transitional cell carcinoma of the bladder. No … " - Cisdiamminedichloroplatinum

Cisdiamminedichloroplatinum

WebCisplatin (cis-Diamminedichloroplatinum) is a organometallic compound and one of several platinum-based antineoplastic agents used in certain types of chemotherapy for the treatment of cancer. These compounds, … WebThe thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensitivity to cis-diamminedichloroplatinum (II) (CDDP).

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WebNov 1, 1983 · cis -Platinum, bleomycin, 5-fluorouracil, and cyclophosphamide were administered to rodent and canine models of osmotic blood-brain barrier modification to evaluate the relationship between tissue drug concentration in brain and the physiological and neuropathological effects of the drug. WebCis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations T. W. Jones, S. Chopra, J. S. Kaufman, W. …

WebCis-diamminedichloroplatinum (II) (DDP) leads the series of platinum coordination complexes, a new class of cytotoxic agents. The antitumor and toxic effects of this drug … WebMay 15, 2015 · The interest in gold(III) as anticancer agent is a result of the current significance of the anticancer cisplatin, cis-diamminedichloroplatinum(II), [PtCl 2 (NH 3) 2] . Although cisplatin has been used for a long time for the treatment of different types of cancer there are several limitations and drawbacks. Gold(III) compounds provided ...

Webcis-Diamminedichloroplatinum (II) - Trait. This product is a crystalline powder of bright yellow to orange yellow; Odorless. This product is soluble in dimethyl sulfoxide, slightly … Webcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163 …

WebA regression rate of 12% (4/33) among patients with advanced upper aerodigestive carcinomas who received an intravenous regimen of cis‐diamminedichloroplatinum, …

WebAbstract Murine leukemia L1210 cells, either sensitive or resistant to the toxic action of the cancer chemotherapeutic agent cis-diamminedichloroplatinum (II), have been studied … duphaston obatWebcis-Diamminedichloroplatinum (II) induced distortion in a double-helical DNA fragment jeroen den hartog 1984, Journal of The American Chemical Society Download Free PDF Related Papers Journal of the … Mechanism of two-electron oxidation of deoxyguanosine 5'-monophosphate by a platinum (IV) complex 2004 • Amanda Hakemian Download Free … cryptic 26377WebJun 1, 1973 · cis -Diamminedichloroplatinum (II) is the first of a group of platinum coordination complexes with antineoplastic activity to be studied in humans. This Phase I investigation characterizes the toxicity and pharmacological disposition of … cryptic 26353WebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ... cryptic 27827WebCisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. Catalog No. NC0564900 $86.10 / Each of 1 Qty Check Availability Add to cart duphaston 10mg dosage in pregnancyWebJun 1, 1975 · Summary. The effects of cis -diamminedichloroplatinum (NSC 119875) on murine and human hemopoietic precursor cells were studied in culture. When murine … cryptic 26347WebJan 1, 1987 · Abstract. Human ovarian cancer cell lines with stable cisplatin resistance have been developed by chronic exposure of the parent cisplatin-sensitive A2780 line to increasing concentrations of cisplatin. 2780CP8 (CP8 refers to this cell line's growth in medium containing 8 µm cisplatin) has several clonal cytogenetic abnormalities but lacks … duphaston tablet benefits