Cisplatin and electrolyte abnormalities
WebJun 8, 2024 · Cisplatin, the active ingredient in Cisplatin injection, is a yellow to orange crystalline powder with the molecular formula Cl 2 H 6 N 2 Pt and a molecular weight of 300.05. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. WebCertain medications may cause an electrolyte imbalance such as: Chemotherapy drugs (cisplatin) Diuretics (furosemide [Lasix] or bumetanide [Bumex]) Antibiotics (amphotericin B) Corticosteroids (hydrocortisone) Symptoms of Electrolyte Imbalance: As described, an electrolyte imbalance may create a number of symptoms.
Cisplatin and electrolyte abnormalities
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WebMay 7, 2024 · For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the … WebMay 1, 2024 · The most common diagnoses were central nervous system tumors (58 [36%]), neuroblastoma (43 [27%]), and osteosarcoma (33 [21%]). Acute kidney injury (by serum creatinine level increase) occurred in 48 of 159 patients (30%) at early cisplatin infusions and 23 of 143 patients (16%) at late cisplatin infusions.
Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage … WebA slight electrolyte imbalance may not cause noticeable changes. When problems occur, you may experience: Confusion and irritability. Diarrhea or constipation. Fatigue. Headaches. Irregular or fast heart rate (arrhythmia). Muscle cramps, muscle spasms or weakness. Nausea and vomiting. Numbness or tingling in limbs, fingers and toes.
WebMay 18, 2024 · Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, … WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium wasting. …
WebDec 15, 2024 · An electrolyte imbalance occurs when your body’s mineral levels are too high or too low. This can negatively affect vital body systems. Electrolytes must be evenly balanced for your body to...
WebPlatelets <50000 Neutrophils <500 Renal Impairment CrCl 41-59 mL/min: 250 mg/m² IV on day 1 CrCl 16-40 mL/min: 200 mg/m² IV on day 1 CrCl <15 mL/min: Not recommended Hepatic Impairment Dose... hunter outdoor fans with remoteWeb• Hypomagnesemia and Accompanying Electrolyte Abnormalities: Monitor during treatment and for at least 8 weeks following the completion. Replete electrolytes as necessary. (5.6) ... and Cisplatin . 5.6 Hypomagnesemia and Accompanying Electrolyte Abnormalities . 5.7 Increased Tumor Progression, Increased Mortality, or Lack ... hunter outfit sea of thievesWebJan 1, 2015 · Similarly, hypomagnesemia exclusive to chemotherapeutic agents like cisplatin, ifosfamide, and cetuximab is only seen in cancer patients. This chapter describes the frequency of the most commonly observed electrolyte disorders in the oncology patient and delves into the unique cancer- or chemotherapy-related etiology of these … hunter outdoor stand fanWebMay 24, 2006 · This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Cisplatin is a well-known nephrotoxic antineoplastic … hunter outlook emailWebIn patients with gynecologic cancers, treated with cisplatin or cisplatin in combination with paclitaxel, a higher incidence of nephrotoxicity in the combination group was noted. 414 In addition, ... Electrolyte abnormalities that may either increase the toxicity of concomitant agents (hypokalemia in patients receiving digoxin) or may be ... hunter outdoor fan remoteWebBichet DG, Anderson RJ, Schrier RW (1993) Renal sodium excretion, edematous disorders, and diuretic use. In: Schrier RW (ed) Renal and electrolyte disorders, 4th edn. Little, Brown and Company, Boston, pp 89–161. Google Scholar Heyman SN, Spokes K, Egorin MJ, Epstein FH (1993) Glycine reduces early parenchymal uptake of cisplatin. hunter outfits tohWebNov 1, 2024 · Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia, hypophosphatemia, hypocalcemia and hyponatremia. hunter outdoor lighting