WebJan 14, 2024 · BORIS (CTCFL), a germline-specific paralog of CTCF, was unable to anchor cohesin to CTCF DNA binding sites. Furthermore, CTCF–BORIS chimeric constructs … WebThis antibody is not cross-reactive with BORIS. Background/Target Information This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences ...
The male germ cell gene regulator CTCFL is functionally different …
WebMay 14, 2002 · The ubiquitous, highly conserved, multivalent 11-zinc-finger (ZF) factor CTCF plays multiple roles in gene regulation, depending on the combinatorial utilization of different ZFs to bind varying CTCF target sites ().CTCF–DNA complex formation can be regulated by CpG-specific DNA methylation (2, 3) if the involved CpG nucleotides are … WebMay 4, 2024 · CCCTC-binding factor (CTCF protein) CTCF protein is a highly conserved key player in helping chromatin fold into 3D structures, and most mammalian TAD borders bind with CTCF [ 13, 33 ]. Xiang and Corces [ 124] reviewed the latest roles of CTCF in regulating 3D chromatin architecture. glazemaster resurfacing reviews
Reciprocal Binding of CTCF and BORIS to the NY-ESO-1 Promoter …
WebOct 1, 2024 · CTCF (CCCTC-binding factor) is a transcription regulator with hundreds of binding sites in the human genome. It has a main function as an insulator protein, defining together with cohesins the boundaries of areas of the genome called topologically associating domains (TADs). TADs contain regulatory elements such as enhancers … WebFeb 1, 2014 · The tumour suppressor gene CTCF can be mutated or deleted in cancer, or CTCF DNA binding can be altered by epigenetic changes. BORIS is aberrantly expressed frequently in cancer, leading some to propose a pro-tumourigenic role for BORIS. However, BORIS can inhibit cell proliferation, and is mutated in cancer similarly to CTCF … WebDec 14, 2011 · BORIS, or CTCFL, the so called Brother of the Regulator of Imprinted Sites because of the extensive homology in the central DNA binding region of the protein to the related regulator, CTCF, is expressed in early gametogenesis and in multiple cancers but not in differentiated somatic cells. Thus it is a member of the cancer testes antigen group … body fat results