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WebAug 19, 2024 · Duloxetine is a type of antidepressant known as a serotonin–norepinephrine reuptake inhibitor used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition … WebApr 16, 2024 · One antidepressant in particular, duloxetine (Cymbalta), is FDA-approved for these conditions. Just how antidepressants reduce pain is not well understood. One possibility is they affect chemicals in the brain involved in pain perception, a mechanism that differs from how they fight depression. Not usually the first choice for pain relief WebFeb 12, 2024 · Mechanism of Action Duloxetine inhibits serotonin and norepinephrine reuptake, thus combining two therapeutic mechanisms in one agent to treat depression … shark nv352 navigator lift away upright