Glycolysis dc sting
Web"Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated… WebJun 5, 2015 · Inhibition of glycolysis also blocks DC maturation in response to LPS, as evidenced by reduced expression of the costimulatory molecules CD80 and CD86 in the presence of 2DG 46. Similarly to ...
Glycolysis dc sting
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WebMay 14, 2024 · STING is a transmembrane protein that regulates DNA-mediated type I interferon-dependent innate immune responses [ 22 ]. During intracellular bacterial … WebJun 1, 2024 · STING and IRF3 are required for spontaneous anti-tumor CD8+ T cell responses and control of tumor growth. Type I IFN production to tumor DNA in DC requires STING, cGAS and IRF3. Empty Cell: IRF3-/-Deng et al. (2014a) IFNAR-/-MC38 + radiation: Type I IFN sensing and STING are required for the anti-tumor effect or radiation.
WebApr 4, 2024 · Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains … WebMar 13, 2024 · Glycolysis is the process by which one molecule of glucose is converted into two molecules of pyruvate, two hydrogen ions and two molecules of water. Through this process, the 'high energy' intermediate molecules of ATP and NADH are synthesised. Pyruvate molecules then proceed to the link reaction, where acetyl-coA is produced. …
WebNational Center for Biotechnology Information WebJun 1, 2024 · Stimulator of interferon gene (STING) is a crucial regulatory signaling molecule in the DNA-sensing pathway, and its activation can produce strong innate immunity. …
WebImportantly, glycolysis facilitated STING-dependent DC activity in tissue samples from non-small cell lung cancer patients. Our results provide mechanistic insight into how the crosstalk of glycolytic metabolism and STING signaling enhances DC antitumor activity and can be harnessed to improve cancer therapies.
WebThe Journal of Clinical Investigation期刊最新论文，,顶级期刊最新论文图文内容，出版社网站每日同步更新，点击标题直达论文原文，自定义关注的期刊，覆盖PubMed的论文库，快速方便精准的找到您想要的论文 tasman gritWebJan 11, 2024 · Macrophages rapidly reprogram their metabolic state to facilitate inflammation, resolution, and effector functions [ 4, 5 ]. The metabolic reprogramming of … 麩 簡単 レシピWebFeb 23, 2024 · Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated … tasman guitar duoWebApr 3, 2024 · Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated glycolysis, and blockade of glycolysis by DC-specific Ldha/Ldhb double deletion resulted … tasman groupWebFeb 17, 2024 · Innate immune cells play the first line of defense against pathogens. Phagocytosis or invasion by pathogens can affect mitochondrial metabolism in macrophages by diverse mechanisms and shape the macrophage response (proinflammatory vs. immunomodulatory) against pathogens. Besides β-nicotinamide adenine dinucleotide 2' … 麩 玉ねぎ 味噌汁WebSep 24, 2024 · The interaction of STAT3 and glycolysis affects STING induction of REG3γ in IECs. Next, we investigated whether STING-induced glycolysis and STAT3 activation affect each other. First, we treated MSIE cells with CMA in the presence or absence of STAT3 inhibitor, HJC0152, for 24 hours, and then measured glycolysis by Seahorse. 麩 晩ごはんWebIn organisms that perform cellular respiration, glycolysis is the first stage of this process. However, glycolysis doesn’t require oxygen, and many anaerobic … 麩 金沢おでん